Journal article

Formation of Polyrotaxane Particles via Template Assembly

Blaise L Tardy, Shereen Tan, Henk H Dam, Tomoya Suma, Junling Guo, Greg G Qiao, Frank Caruso

BIOMACROMOLECULES | AMER CHEMICAL SOC | Published : 2017

Abstract

In this study, we report a versatile method to assemble tunable poly(ethylene glycol) (PEG)-based polyrotaxane (PRX) particles and capsules. By threading α-cyclodextrins (αCDs) onto PEG chains physically adsorbed onto template particles and subsequently dissolving the templates, PRX replica particles and hollow capsules are formed. This approach overcomes issues related to CD steric hindrance, and also reduces the multiple processing steps often associated with PRX-based particle formation. By simple variation of the molecular weight and end-group functionality of the PEG, we show that the rate of particle degradation as well as the stability of the particles can be tuned. We also demonstrat..

View full abstract

Grants

Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by ARC


Funding Acknowledgements

This research was in part conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (Project Number CE140100036), and the ARC under the Australian Laureate Fellowship (FL120100030, F.C) scheme. This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at the University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF). The authors would like to thank Dr. Yi Ju for assistance with particle preparation, and Farshad Motevalizadeh for assistance with TGA