Journal article
IL-17-producing γδ T cells switch migratory patterns between resting and activated states
DR McKenzie, EE Kara, CR Bastow, TS Tyllis, KA Fenix, CE Gregor, JJ Wilson, R Babb, JC Paton, A Kallies, SL Nutt, A Brüstle, M Mack, I Comerford, SR McColl
Nature Communications | NATURE PUBLISHING GROUP | Published : 2017
DOI: 10.1038/ncomms15632
Abstract
Interleukin 17-producing γδ T (γδT17) cells have unconventional trafficking characteristics, residing in mucocutaneous tissues but also homing into inflamed tissues via circulation. Despite being fundamental to γδ T17-driven early protective immunity and exacerbation of autoimmunity and cancer, migratory cues controlling γδT17 cell positioning in barrier tissues and recruitment to inflammatory sites are still unclear. Here we show that γδT17 cells constitutively express chemokine receptors CCR6 and CCR2. While CCR6 recruits resting γδT17 cells to the dermis, CCR2 drives rapid γδT17 cell recruitment to inflamed tissues during autoimmunity, cancer and infection. Downregulation of CCR6 by IRF4 ..
View full abstractGrants
Awarded by National Science Foundation
Funding Acknowledgements
We thank Prof. Ian Frazer (UQ Diamantina Institute, Australia), Prof. Brigitta Stockinger (Francis Crick Institute, UK) and Prof. Christian Engwerda (QIMR Berghofer, Australia) for mice and Prof. Dan Littman (New York University, USA) for pMIG-Rorc (Addgene #24069). We also thank the late Prof. Ian Clark-Lewis for chemokine ligands and staff at Laboratory Animal Services from University of Adelaide for animal husbandry. This work was supported by National Health and Medical Research Council project grants 1066781 and 1054925. A.K. is supported by the Sylvia and Charles Viertel foundation.