Journal article

Evolution of the Pygmy Phenotype: Evidence of Positive Selection from Genome-wide Scans in African, Asian, and Melanesian Pygmies

Andrea Bamberg Migliano, Irene Gallego Romero, Mait Metspalu, Matthew Leavesley, Luca Pagani, Tiago Antao, Da-Wei Huang, Brad T Sherman, Katharine Siddle, Clarissa Scholes, Georgi Hudjashov, Elton Kaitokai, Avis Babalu, Maggie Belatti, Alex Cagan, Bryony Hopkinshaw, Colin Shaw, Mari Nelis, Ene Metspalu, Reedik Maegi Show all

HUMAN BIOLOGY | WAYNE STATE UNIV PRESS | Published : 2013

Abstract

Human pygmy populations inhabit different regions of the world, from Africa to Melanesia. In Asia, short-statured populations are often referred to as "negritos." Their short stature has been interpreted as a consequence of thermoregulatory, nutritional, and/or locomotory adaptations to life in tropical forests. A more recent hypothesis proposes that their stature is the outcome of a life history trade-off in high-mortality environments, where early reproduction is favored and, consequently, early sexual maturation and early growth cessation have coevolved. Some serological evidence of deficiencies in the growth hormone/insulin-like growth factor axis have been previously associated with pyg..

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University of Melbourne Researchers

Grants

Awarded by Estonian Basic Research grant


Awarded by Tartu University grant


Funding Acknowledgements

This project was funded by a Clare College fellowship, a Newnham Gibbs travel fellowship, and the Leverhulme Programme Grant/Hunter-Gatherers Resilience to A.B.M.; a Natural Environment Research Council (NERC)/Environmental Factors in the Chronology of Human Evolution and Dispersal Programme (EFCHED) grant to M.M.L.; the E.U. European Regional Development Fund through the Centre of Excellence in Genomics and Estonian Basic Research grant SF0182474 to R.V.; and Tartu University grant PBGMR06901 to T.K.