Journal article

Comparative studies of gene expression and the evolution of gene regulation

Irene Gallego Romero, Ilya Ruvinsky, Yoav Gilad

Nature Reviews Genetics | NATURE PUBLISHING GROUP | Published : 2012


The hypothesis that differences in gene regulation have an important role in speciation and adaptation is more than 40 years old. With the advent of new sequencing technologies, we are able to characterize and study gene expression levels and associated regulatory mechanisms in a large number of individuals and species at an unprecedented resolution and scale. We have thus gained new insights into the evolutionary pressures that shape gene expression levels and have developed an appreciation for the relative importance of evolutionary changes in different regulatory genetic and epigenetic mechanisms. The current challenge is to link gene regulatory changes to adaptive evolution of complex ph..

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University of Melbourne Researchers


Awarded by US National Science Foundation

Awarded by US National Institutes of Health (NIH)

Awarded by NIH


Funding Acknowledgements

We thank M. Nobrega and N. Sakab for helping to generate Fig. 1, M. Ward and D. Odom for generating Fig. 2 on the basis of their comparative data and G. Perry for help with the figures in Boxes 2 and 3. We thank J. Pritchard, Z. Gauhar and the three anonymous reviewers for their comments on the manuscript. This work was supported by US National Science Foundation grant IOS-0843504 and US National Institutes of Health (NIH) grant P50 GM081892 to I.R., and NIH grants GM077959 and GM084996 to Y.G. I.G.R. is a Sir Henry Wellcome Postdoctoral Fellow.