Journal article

The influence of hippocampal atrophy on the cognitive phenotype of dementia with Lewy bodies

Greg J Elder, Karen Mactier, Sean J Colloby, Rosie Watson, Andrew M Blamire, John T O'Brien, John-Paul Taylor

International Journal of Geriatric Psychiatry | WILEY | Published : 2017

Abstract

OBJECTIVE: The level of hippocampal atrophy in dementia with Lewy bodies (DLB) is typically less than that observed in Alzheimer's disease (AD). However, it is not known how the cognitive phenotype of DLB is influenced by hippocampal atrophy or the atrophy of adjacent medial temporal lobe structures. METHODS: Dementia with Lewy bodies (n = 65), AD (n = 76) and control (n = 63) participants underwent 3T magnetic resonance imaging and cognitive Cambridge Cognitive Examination and Mini-Mental State Examination (CAMCOG and MMSE) assessments. Hippocampal volume, and parahippocampal, entorhinal and temporal pole cortical thickness, was compared between groups. Regression models were used to invest..

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Grants

Awarded by Wellcome Trust


Awarded by Wellcome Intermediate Clinical Fellowship


Awarded by Sir Jules Thorn Charitable Trust


Funding Acknowledgements

This research was supported by the following: Wellcome Trust Starter Grants scheme for Clinical Lecturers (BH090112 to J-P.T.); Wellcome Intermediate Clinical Fellowship (BH083281 to J-P.T.); the Sir Jules Thorn Charitable Trust (05/JTA) and by the National Institute of Health Research (NIHR) Newcastle Biomedical Research Unit based at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health.