Journal article

Cortical and Subcortical Changes in Alzheimer's Disease: A Longitudinal and Quantitative MRI Study

Li Su, Andrew M Blamire, Rosie Watson, Jiabao He, Benjamin Aribisala, John T O'Brien

Current Alzheimer Research | BENTHAM SCIENCE PUBL LTD | Published : 2016

Abstract

Quantitative MRI provides important information about tissue properties in brain both in normal ageing and in degenerative disorders. Although it is well known that those with Alzheimer's disease (AD) show a specific pattern and faster rate of atrophy than controls, the precise spatial and temporal patterns of quantitative MRI in AD are unknown. We aimed to investigate neuroimaging correlates of AD using serial quantitative MRI. In our study, twenty-one subjects with AD and thirty-two similar-aged healthy controls underwent two serial MRI scans at baseline and 12 months. Tissue characteristics were captured using two quantitative MRI parameters: longitudinal relaxation time (qT1) and transve..

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Grants

Awarded by Sir Jules Thorn Charitable Trust


Awarded by Medical Research Council


Funding Acknowledgements

The study was funded by the Sir Jules Thorn Charitable Trust (grant ref: 05/JTA) and was supported by the National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre and the Biomedical Research Unit in Lewy Body Dementia based at Newcastle upon Tyne Hospitals National Health Service (NHS) Foundation Trust and Newcastle University and the NIHR Biomedical Research Centre and Biomedical Research Unit in Dementia based at Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. L. Su, A. Blamire, R. Watson, J. He and B. Aribisala report no disclosures. J. O'Brien has been a consultant for GE Healthcare, Servier, and Bayer Healthcare and has received honoraria for talks from Pfizer, GE Healthcare, Eisai, Shire, Lundbeck, Lilly, and Novartis.