Journal article

Assessment of regional MR diffusion changes in dementia with Lewy bodies and Alzheimer's disease

James O'Donovan, Rosie Watson, Sean J Colloby, Andrew M Blamire, John T O'Brien

INTERNATIONAL PSYCHOGERIATRICS | CAMBRIDGE UNIV PRESS | Published : 2014

Abstract

BACKGROUND: Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are common forms of dementia, yet diagnosis is often difficult. Diffusion tensor imaging (DTI) is an MR technique used to assess neuronal microstructural integrity that may help develop a better understanding of the differences between the conditions. METHODS: We recruited subjects with DLB (n = 35), AD (n = 36), and similar aged healthy controls (n = 35). T1 weighted anatomical and diffusion MR images were acquired at 3 Tesla. Region of interest (ROI) analysis was used to measure fractional anisotropy (FA) and mean diffusivity (MD) in five structures: precuneus, thalamus, pons, midbrain, and amygdala. Where appropriate..

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Grants

Awarded by Sir Jules Thorn Charitable Trust


Awarded by The Sir Jules Thorn Charitable Trust


Funding Acknowledgements

We thank Dr Robert Barber for providing assistance with subject diagnostic rating as well as Josh Wood, Assistant Psychologist, and the members of North East Dementias and Neurodegenerative Diseases Research network (NE-DeNDRoN) for their assistance with recruitment and assessment of study participants. We are also grateful to all of the study volunteers for their involvement. The study was supported by the Sir Jules Thorn Charitable Trust (grant number 05/JTA), The Jean Shanks Foundation, and the UK NIHR Biomedical Research Centre and Biomedical Research Unit in Lewy body dementia awarded to the Newcastle upon Tyne Hospitals NHS Foundation Trust and the NIHR Biomedical Research Centre and Biomedical Research Unit in Dementia awarded to Cambridge University Hospitals NHS Trust and the University of Cambridge.