Journal article

Distinct cognitive phenotypes in Alzheimer's disease in older people

Emma RLC Vardy, Andrew H Ford, Peter Gallagher, Rosie Watson, Ian G McKeith, Andrew Blamire, John T O'Brien



BACKGROUND: Alzheimer's disease (AD) is considered to be a disorder predominantly affecting memory. It is increasingly recognized that the cognitive profile may be heterogeneous. We hypothesized that it would be possible to define distinct “cognitive phenotypes” in older people with AD. METHODS: Participants from three individual studies were included, consisting of 109 patients with a diagnosis of probable AD, and 91 age- and gender-matched control participants. All had demographic and cognitive assessment data available, including the Cambridge Cognitive Examination of the Elderly (CAMCOG). The CAMCOG scores and sub-scores were further analyzed using hierarchical cluster analysis and facto..

View full abstract


Awarded by National Institute for Health Research

Awarded by The Sir Jules Thorn Charitable Trust

Funding Acknowledgements

The study was funded by the Sir Jules Thorn Charitable Trust Medical Research Council of Great Britain and the National Institute for Health Research (NIHR). The research was supported by the NIHR Newcastle Biomedical Research Centre in Ageing and Chronic Disease and Biomedical Research Unit in Lewy Body Dementia based at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, and the NIHR Biomedical Research Unit in Dementia awarded to Cambridge University Hospitals NHS Trust and the University of Cambridge. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health.