Journal article

Does posterior cortical atrophy on MRI discriminate between Alzheimer's disease, dementia with Lewy bodies, and normal aging?

James O'Donovan, Rosie Watson, Sean J Colloby, Michael J Firbank, Emma J Burton, Robert Barber, Andrew M Blamire, John T O'Brien

INTERNATIONAL PSYCHOGERIATRICS | CAMBRIDGE UNIV PRESS | Published : 2013

Abstract

BACKGROUND: Previous studies suggest that posterior cortical atrophy may be a useful marker for early onset Alzheimer's disease (AD). Dementia with Lewy bodies (DLB) is associated with less temporal lobe atrophy than AD, though posterior cortical atrophy may be greater. Therefore, we assessed whether visual rating scales for assessing posterior atrophy (PA), medial temporal lobe atrophy (MTA), and ventricular enlargement (VEn) aid in the discrimination between AD, DLB, and normal aging. METHODS: T1-weighted MRI scans acquired at 3 Tesla were visually rated for PA (range 0-3), MTA (range 0-4), and VEn (range 0-3) in older subjects with AD (n = 36), DLB (n = 35), and healthy controls (n = 35)...

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Grants

Awarded by Sir Jules Thorn Charitable Trust


Awarded by Medical Research Council


Awarded by The Sir Jules Thorn Charitable Trust


Funding Acknowledgements

We thank Josh Wood, Assistant Psychologist, and members of NE-DeNDRoN for their assistance with recruitment and assessment of study participants. This study was supported by the Sir Jules Thorn Charitable Trust (grant number 05/JTA) and the UK NIHR Biomedical Research Centre for Ageing and Age Related Diseases award to the Newcastle upon Tyne Hospitals NHS Foundation Trust. The Wellcome Trust provided funding for a six-week vacation studentship.