Journal article

Does posterior cortical atrophy on MRI discriminate between Alzheimer's disease, dementia with Lewy bodies, and normal aging?

James O'Donovan, Rosie Watson, Sean J Colloby, Michael J Firbank, Emma J Burton, Robert Barber, Andrew M Blamire, John T O'Brien



BACKGROUND: Previous studies suggest that posterior cortical atrophy may be a useful marker for early onset Alzheimer's disease (AD). Dementia with Lewy bodies (DLB) is associated with less temporal lobe atrophy than AD, though posterior cortical atrophy may be greater. Therefore, we assessed whether visual rating scales for assessing posterior atrophy (PA), medial temporal lobe atrophy (MTA), and ventricular enlargement (VEn) aid in the discrimination between AD, DLB, and normal aging. METHODS: T1-weighted MRI scans acquired at 3 Tesla were visually rated for PA (range 0-3), MTA (range 0-4), and VEn (range 0-3) in older subjects with AD (n = 36), DLB (n = 35), and healthy controls (n = 35)...

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Awarded by Sir Jules Thorn Charitable Trust

Awarded by Medical Research Council

Awarded by The Sir Jules Thorn Charitable Trust

Funding Acknowledgements

We thank Josh Wood, Assistant Psychologist, and members of NE-DeNDRoN for their assistance with recruitment and assessment of study participants. This study was supported by the Sir Jules Thorn Charitable Trust (grant number 05/JTA) and the UK NIHR Biomedical Research Centre for Ageing and Age Related Diseases award to the Newcastle upon Tyne Hospitals NHS Foundation Trust. The Wellcome Trust provided funding for a six-week vacation studentship.