Journal article

Characterizing dementia with Lewy bodies by means of diffusion tensor imaging

Rosie Watson, Andrew M Blamire, Sean J Colloby, Josh S Wood, Robert Barber, Jiabao He, John T O'Brien



OBJECTIVE: To investigate patterns of in vivo white matter tract change using diffusion tensor imaging (DTI), we conducted a cross-sectional study of dementia with Lewy bodies (DLB) in comparison with Alzheimer disease (AD) and normal aging. METHODS: The study included 106 subjects (35 with DLB, 36 with AD, and 35 elderly controls) who underwent clinical and neuropsychological assessment and diffusion tensor MRI. We used tract-based spatial statistics to investigate patterns of reduced fractional anisotropy (FA) and increased mean diffusivity (MD) across the entire white matter tract skeleton and also investigated correlations with clinical features. RESULTS: Areas of reduced FA in subjects ..

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Awarded by Sir Jules Thorn Charitable Trust

Awarded by The Sir Jules Thorn Charitable Trust

Funding Acknowledgements

The study was funded by the Sir Jules Thorn Charitable Trust (grant ref: 05/JTA) and was supported by a UK NIHR Biomedical Research Centre for Ageing and Age-Related Disease Award to the Newcastle upon Tyne Hospitals NHS Foundation Trust (grant ref: Newcastle BRC).