Progressive Decline in Hippocampal CA1 Volume in Individuals at Ultra-High-Risk for Psychosis Who Do Not Remit: Findings from the Longitudinal Youth at Risk Study

NF Ho; DJ Holt; M Cheung; JE Iglesias; A Goh; M Wang; JK Lim; J De Souza; JS Poh; YM See; AR Adcock; SJ Wood; MW Chee; J Lee; J Zhou

Journal article

Progressive Decline in Hippocampal CA1 Volume in Individuals at Ultra-High-Risk for Psychosis Who Do Not Remit: Findings from the Longitudinal Youth at Risk Study

NF Ho, DJ Holt, M Cheung, JE Iglesias, A Goh, M Wang, JK Lim, J De Souza, JS Poh, YM See, AR Adcock, SJ Wood, MW Chee, J Lee, J Zhou

Neuropsychopharmacology | NATURE PUBLISHING GROUP | Published : 2017

DOI: 10.1038/npp.2017.5

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Abstract

Most individuals identified as ultra-high-risk (UHR) for psychosis do not develop frank psychosis. They continue to exhibit subthreshold symptoms, or go on to fully remit. Prior work has shown that the volume of CA1, a subfield of the hippocampus, is selectively reduced in the early stages of schizophrenia. Here we aimed to determine whether patterns of volume change of CA1 are different in UHR individuals who do or do not achieve symptomatic remission. Structural MRI scans were acquired at baseline and at 1-2 follow-up time points (at 12-month intervals) from 147 UHR and healthy control subjects. An automated method (based on an ex vivo atlas of ultra-high-resolution hippocampal tissue) was..

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University of Melbourne Researchers

Stephen Wood Author

Grants

Awarded by National Institute of Mental Health

Funding Acknowledgements

This work was supported by the National Medical Research Council Translational and Clinical Research Flagship Programme (grant number NMRC/TCR/003/2008), Biomedical Research Council, Singapore (grant number BMRC 04/1/36/19/372 to JZ), National Medical Research Council, Singapore (grant number CBRG/0088/2015 to JZ), and National Medical Research Council Centre Grant Programme (grant number NMRC/CG/004/2013 to NFH). JL is further supported by the National Healthcare Group Clinician Scientist Career Scheme. JEI is supported by a Marie Sklodowska-Curie fellowship (Project No. 654911 'THALAMODEL') and by the Spanish Ministry of Economy and Competitiveness (reference TEC2014-51882-P). DJH is supported by the National Institute of Mental Health (grant number RO1MH095904). The funding bodies had no roles in the design of the study, collection and analysis of data, and decision to publish.