Journal article

The 5-HT(1A) receptor knockout mouse and anxiety.

B Olivier, T Pattij, SJ Wood, R Oosting, Z Sarnyai, M Toth

Behavioural Pharmacology | Published : 2001


The 5-HT(1A) receptor has been implicated in the modulation of anxiety processes, mainly via pharmacological experiments. The recent production, in three independent research groups, of 5-HT(1A) receptor knockout (R KO) mice in three different genetic backgrounds (C57BL/6J, 129/Sv, Swiss-Webster) led to the intriguing finding that all mice, independent from the genetic background strain from which the null mutants were made, showed an "anxious" phenotype compared to corresponding wild-type mice. The present paper reviews the behavioral findings in these three KO lines and focuses on new findings in the 129/Sv-KO mice. These mice were more anxious or stress-prone only under specific condition..

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University of Melbourne Researchers