Journal article

Molecular pathways of anxiety revealed by knockout mice.

SJ Wood, M Toth

Molecular Neurobiology | Published : 2001


Anxiety is a normal reaction to threatening situations, and serves a physiological protective function. Pathological anxiety is characterized by a bias to interpret ambiguous situations as threatening, by avoidance of situations that are perceived to be harmful, and/or by exaggerated reactions to threat. Although much evidence indicates the involvement of the gamma-aminobutyric acid, serotonin, norepinephrine, dopamine, and neuropeptide transmitter systems in the pathophysiology of anxiety, little is known about how anxiety develops and what genetic/environmental factors underlie susceptibility to anxiety. Recently, inactivation of several genes, associated with either chemical communication..

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University of Melbourne Researchers


Awarded by NIMH NIH HHS

Awarded by NINDS NIH HHS