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No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease

Michelle K Lupton, Beben Benyamin, Petroula Proitsi, Dale R Nyholt, Manuel A Ferreira, Grant W Montgomery, Andrew C Heath, Pamela A Madden, Sarah E Medland, Scott D Gordon, Simon Lovestone, Magda Tsolaki, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Vellas, John F Powell, Ashley I Bush, Margaret J Wright, Nicholas G Martin Show all

Journal of Alzheimer's Disease | IOS PRESS | Published : 2017


Awarded by European Union of the Sixth Framework program priority

Awarded by Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health)

Awarded by DOD ADNI (Department of Defense)

Awarded by Wellcome Trust

Awarded by Australian National Health and Medical Research Council (NHMRC)

Awarded by US National Institutes of Health (NIH)

Awarded by Australian Research Council (ARC)

Awarded by Australian National Health and Medical Research Council

Awarded by Medical Research Council

Awarded by Alzheimer's Research UK

Awarded by German Federal Ministry of Education and Research (BMBF): Competence Network Dementia (CND)

Awarded by NIH/NIA grant

Awarded by NIA

Awarded by AGES

Awarded by NHLBI

Awarded by NIH/NIA grants

Awarded by Alzheimer's Association

Funding Acknowledgements

For the GERAD1 Consortium: Cardiff University was supported by the Wellcome Trust, Medical Research Council (MRC), Alzheimer's Research UK (ARUK), and the Welsh Assembly Government. ARUK supported sample collections at the Kings College London; the South West Dementia Bank; and Universities of Cambridge, Nottingham, Manchester, and Belfast. The Belfast group acknowledges support from the Alzheimer's Society, Ulster Garden Villages, N. Ireland R&D Office, and the Royal College of Physicians/Dunhill Medical Trust. The MRC and Mercer's Institute for Research on Ageing supported the Trinity College group. The South West Dementia Brain Bank acknowledges support from Bristol Research into Alzheimer's and Care of the Elderly. The Charles Wolfson Charitable Trust supported the OPTIMA group. Washington University was funded by NIH grants, Barnes Jewish Foundation, and the Charles and Joanne Knight Alzheimer's Research Initiative. Patient recruitment for the MRC Prion Unit/UCL Department of Neurodegenerative Disease collection was supported by the UCLH/UCL Biomedical Centre. LASER-AD was funded by Lundbeck SA. The Bonn group was supported by the German Federal Ministry of Education and Research (BMBF), Competence Network Dementia and Competence Network Degenerative Dementia, and by the Alfried Krupp von Bohlen und Halbach-Stiftung. The GERAD1 Consortium also used samples ascertained by the NIMH AD Genetics Initiative.AddNeuroMed is part of InnoMed (Innovative Medicines in Europe), an integrated project funded by the European Union of the Sixth Framework program priority ((FP6-2004-LIFESCIHEALTH-5); the Alzheimer's Research Trust UK; the John and Lucille van Geest Foundation; and the NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at the South London, Maudsley NHS Foundation Trust and Kings College London, and a joint infrastructure grant from Guy's and St Thomas' Charity and the Maudsley Charity; Academy of Finland, Kuopio University Hospital (HS) and funding from UEF-BRAIN (HS).The Kings Health Partners Dementia Case Register is funded by the National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre and Dementia Unit at South London and Maudsley NHS Foundation Trust and (Institute of Psychiatry, Psychology and Neuroscience) King's College London.Data collection and sharing for ADNI was funded by the Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01 AG024904) and DOD ADNI (Department of Defense award number W81XWH-12-2-0012). ADNI is funded by the National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering, and through generous contributions from the following: Alzheimer's Association; Alzheimer's Drug Discovery Foundation; Araclon Biotech; BioClinica, Inc.; Biogen Idec Inc.; Bristol-Myers Squibb Company; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company; EuroImmun; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; Fujirebio; GE Healthcare;; IXICO Ltd.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Medpace, Inc.; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; NeuroRx Research; Neurotrack Technologies; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Piramal Imaging; Servier; Synarc Inc.; and Takeda Pharmaceutical Company. The Canadian Institutes of Health Research is providing funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health ( The grantee organization is the Northern California Institute for Research and Education, and the study is coordinated by the Alzheimer's Disease Cooperative Study at the University of California, San Diego. ADNI data are disseminated by the Laboratory for Neuro Imaging at the University of Southern California.This study makes use of data generated by the Wellcome Trust Case-Control Consortium. A full list of the investigators who contributed to the generation of the data is available from Funding for the project was provided by the Wellcome Trust under award 076113 and 085475" and cite the relevant primary WTCCC publication (details of which can be found on the WTCCC website).For the Australian study, we acknowledge funding from the Australian National Health and Medical Research Council (NHMRC grants 241944, 389875, 389891, 389892, 389938, 442915, 442981, 496739 and 552485), US National Institutes of Health (NIH grants AA07535, AA10248, AA014041, AA011998, AA013320, AA013321, AA017688, DA012854), and the Australian Research Council (ARC grant DP0770096). MKL is supported by a Perpetual Foundation Wilson Fellowship for early career researchers.BB was supported by the Australian National Health and Medical Research Council (APP1084417 and APP1079583).We thank the International Genomics of Alzheimer's Project (IGAP) for providing AD meta-analysis summary results data for these analyses. The investigators within IGAP contributed to the design and implementation of IGAP and/or provided data but did not participate in analysis or writing of this report. IGAP was made possible by the generous participation of the control subjects, the patients, and their families. The i-Select chips were funded by the French National Foundation on Alzheimer's disease and related disorders. EADI was supported by the LABEX (laboratory of excellence program investment for the future) DISTALZ grant, Inserm, Institut Pasteur de Lille, Universite de Lille 2 and the Lille University Hospital. GERAD was supported by the Medical Research Council (Grant no 503480), Alzheimer's Research UK (Grant no 503176), the Wellcome Trust (Grant no 082604/2/07/Z) and German Federal Ministry of Education and Research (BMBF): Competence Network Dementia (CND) grant no 01GI0102, 01GI0711, 01GI0420. CHARGE was partly supported by the NIH/NIA grant R01 AG033193 and the NIA AG081220 and AGES contract N01-AG-12100, the NHLBI grant R01 HL105756, the Icelandic Heart Association, and the Erasmus Medical Centre and Erasmus University. ADGC was supported by the NIH/NIA grants: U01 AG032984, U24 AG021886, U01 AG016976, and the Alzheimer's Association grant ADGC-10-196728.