Journal article
A Helicobacter pylori homolog of eukaryotic flotillin is involved in cholesterol accumulation, epithelial cell responses and host colonization
ML Hutton, K D'Costa, AE Rossiter, L Wang, L Turner, DL Steer, SL Masters, BA Croker, M Kaparakis-Liaskos, RL Ferrero
Frontiers in Cellular and Infection Microbiology | FRONTIERS MEDIA SA | Published : 2017
Abstract
The human pathogen Helicobacter pylori acquires cholesterol from membrane raft domains in eukaryotic cells, commonly known as "lipid rafts." Incorporation of this cholesterol into the H. pylori cell membrane allows the bacterium to avoid clearance by the host immune system and to resist the effects of antibiotics and antimicrobial peptides. The presence of cholesterol in H. pylori bacteria suggested that this pathogen may have cholesterol-enriched domains within its membrane. Consistent with this suggestion, we identified a hypothetical H. pylori protein (HP0248) with homology to the flotillin proteins normally found in the cholesterol-enriched domains of eukaryotic cells. As shown for eukar..
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Awarded by Seventh Framework Programme
Funding Acknowledgements
This project was supported by funding from the National Health and Medical Research Council (NHMRC) to RF and BC (project APP1030243). Research at the Hudson Institute of Medical Research is supported by the Victorian Government's Operational Infrastructure Support Program. RF and AR are supported by fellowships from the NHMRC (SRF GTN606476 and APP1079904) and Wellcome Trust (Sir Henry Postdoctoral Fellow), respectively. MH was supported by a Monash University Graduate Scholarship and Australian Postgraduate Award (APA). KD is supported by an International Postgraduate Scholarship (Monash University Faculty of Medicine, Nursing and Health Sciences) and by the Centre for Innate Immunity and Infectious Diseases. LT was funded by an APA and a Monash University Faculty of Medicine, Nursing, and Health Sciences Excellence Award.