Journal article
HLA-A*24:02 as a common risk factor for antiepileptic drug-induced cutaneous adverse reactions
Yi-Wu Shi, Fu-Li Min, Dong Zhou, Bin Qin, Juan Wang, Fa-Yun Hu, Ying-Kit Cheung, Jin-Hua Zhou, Xiang-Shu Hu, Jue-Qian Zhou, Lie-Min Zhou, Zhong-zheng Zheng, Jie Pan, Na He, Zhi-Sheng Liu, Yun-Qi Hou, Kheng-Seang Lim, Yang-mei Ou, Amy Hui-Ping Khor, Ching-Ching Ng Show all
NEUROLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017
Abstract
OBJECTIVE: To investigate the involvement of human leukocyte antigen (HLA) loci in aromatic antiepileptic drug-induced cutaneous adverse reactions. METHODS: A case-control study was performed to detect HLA loci involved in aromatic antiepileptic drug-induced Stevens-Johnson syndrome in a southern Han Chinese population. Between January 1, 2006, and December 31, 2015, 91 cases of Stevens-Johnson syndrome induced by aromatic antiepileptic drugs and 322 matched drug-tolerant controls were enrolled from 8 centers. Important genotypes were replicated in cases with maculopapular eruption and in the meta-analyses of data from other populations. Sequence-based typing determined the HLA-A, HLA-B, HLA..
View full abstractGrants
Awarded by National Natural Science Foundation of China
Awarded by Science and Technology Project of Guangdong Province
Awarded by Department of Education of Guangdong Province
Awarded by Foundation for High-Level Talents in Higher Education of Guangdong
Awarded by Yangcheng Scholar Research Project of Guangzhou Municipal College
Awarded by Science and Technology Project of Guangzhou
Awarded by Hong Kong Health and Health Services Research
Funding Acknowledgements
This work was funded by the National Natural Science Foundation of China (grants 81271434, 81301107, 81571273, 81571274, 81501124, and 81601136), the Science and Technology Project of Guangdong Province (grant 2013B051000084), the Department of Education of Guangdong Province (grants 2013CXZDA022, 2013KJCX0156, and 2015KCXTD024), the Foundation for High-Level Talents in Higher Education of Guangdong (grant 2013-167), the Yangcheng Scholar Research Project of Guangzhou Municipal College (grants 12A016S and 12A017G), the Science and Technology Project of Guangzhou (grants 2014J4100069 and 201508020011), the Collaborative Innovation Center for Neurogenetics and Channelopathies, and the Hong Kong Health and Health Services Research (grant 07080381). The funders had no role in study design, data collection, and analysis or in the decision to publish or the preparation of the manuscript.