Journal article

An individualised risk-adapted protocol of pre-and post transplant zoledronic acid reduces bone loss after allogeneic stem cell transplantation: results of a phase II prospective trial

A Grigg, B Butcher, B Khodr, A Bajel, M Hertzberg, S Patil, AB D'Souza, P Ganly, P Ebeling, E Wong

BONE MARROW TRANSPLANTATION | NATURE PUBLISHING GROUP | Published : 2017

Abstract

Bone loss occurs frequently following allogeneic haematopoietic stem cell transplantation (alloSCT). The Australasian Leukaemia and Lymphoma Group conducted a prospective phase II study of pretransplant zoledronic acid (ZA) and individualised post-transplant ZA to prevent bone loss in alloSCT recipients. Patients received ZA 4 mg before conditioning. Administration of post-transplant ZA from days 100 to 365 post alloSCT was determined by a risk-adapted algorithm based on serial bone density assessments and glucocorticoid exposure. Of 82 patients enrolled, 70 were alive and without relapse at day 100. A single pretransplant dose of ZA prevented femoral neck bone loss at day 100 compared with ..

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University of Melbourne Researchers