Neuropsychiatric symptoms and immune activation in patients with genital herpes.
Uté Vollmer-Conna, Marcus Chen, Andrew Lloyd, Basil Donovan
Acta Neuropsychiatr | Published : 2008
OBJECTIVE: Neuropsychiatric disturbances are common among patients with genital herpes simplex virus (HSV) infection. To date, no studies have examined the possible role of immune activation in the aetiology of these disturbances. The aim of this study was to examine the relationship between markers of immune activation and measures of emotional and somatic dysfunction among patients with symptomatic genital herpes. METHODS: Twenty-two patients with documented genital herpes were assessed when herpetic lesions were present and when they were not. Each assessment included a clinical examination, self-reported symptom measures as well as a blood and urine collection. Markers of immune activati..View full abstract