International Guillain-Barré Syndrome Outcome Study: protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome

BC Jacobs; B van den Berg; C Verboon; G Chavada; DR Cornblath; KC Gorson; T Harbo; HP Hartung; RAC Hughes; S Kusunoki; PA van Doorn; HJ Willison; DR Cornblath; M van Woerkom; J Roodbol; RC Reisin; SW Reddel; Z Islam; B Islam; QD Mohammad; P van den Bergh; TE Feasby; YZ Wang; Y Péréon; HC Lehmann; E Dardiotis; E Nobile-Orazio; S Kusunoki; N Shahrizaila; K Bateman; I Illa; LA Querol; ST Hsieh; A Davidson; JM Addington; S Ajroud-Driss; H Andersen; G Antonini; S Attarian; U Badrising; FA Barroso; L Benedetti; A Beronio; M Bianco; D Binda; C Briani; J Bürmann; IR Bella; TE Bertorini; R Bhavaraju-Sanka; TH Brannagan; M Busby; S Butterworth; M Campagnolo; C Casasnovas; G Cavaletti; CS Chao; S Chen; S Chetty; KG Claeys; JA Cohen; ME Conti; JS Cosgrove; MC Dalakas; MM Dimachkie; U Dillmann; C Domínguez González; K Doppler; C Dornonville de la Cour; A Echaniz-Laguna; F Eftimov; CG Faber; R Fazio; C Fokke; T Fujioka; EA Fulgenzi; G Galassi; T Garcia; M Garnero; MPJ Garssen; CJ Gijsbers

Journal article

International Guillain-Barré Syndrome Outcome Study: protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome

BC Jacobs, B van den Berg, C Verboon, G Chavada, DR Cornblath, KC Gorson, T Harbo, HP Hartung, RAC Hughes, S Kusunoki, PA van Doorn, HJ Willison, DR Cornblath, M van Woerkom, J Roodbol, RC Reisin, SW Reddel, Z Islam, B Islam, QD Mohammad Show all

Journal of the Peripheral Nervous System | WILEY | Published : 2017

DOI: 10.1111/jns.12209

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Abstract

Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical presentation, course, and outcome. The factors that determine the clinical variation of GBS are poorly understood which complicates the care and treatment of individual patients. The protocol of the ongoing International GBS Outcome Study (IGOS), a prospective, observational, multicenter cohort study that aims to identify the clinical and biological determinants and predictors of disease onset, subtype, course and outcome of GBS is presented here. Patients fulfilling the diagnostic criteria for GBS, regardless of age, disease severity, variant forms, or treatment, can participate if included with..

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University of Melbourne Researchers

Lynette Kiers Author

Grants

Awarded by CSL Behring

Funding Acknowledgements

The IGOS study protocol was developed without external financial support. The development of a web-based data entry support was supported by funding from the GBS-CIDP Foundation International (https://www.gbs-cidp.org/). Additional funding to support the conduct of IGOS for specific countries or projects was received from gain (http://www.gaincharity.org.uk/), Erasmus MC, Rotterdam, The Netherlands, University of Glasgow, Glasgow, UK, Grifols, CSL Behring, Shire Pharmaceuticals and Annexon. IGOS is scientifically independent, and the funding agencies have no influence on the study and infrastructure design of IGOS, nor on the collection, statistical analysis and interpretation of the data collected in IGOS, nor on the writing, publication of manuscripts or other presentations based on these data.