Journal article
Neurocognitive subtypes in patients with bipolar disorder and their unaffected siblings
M Russo, TE Van Rheenen, M Shanahan, K Mahon, MM Perez-Rodriguez, A Cuesta-Diaz, E Larsen, AK Malhotra, KE Burdick
Psychological Medicine | CAMBRIDGE UNIV PRESS | Published : 2017
Abstract
Background Our previous work revealed substantial heterogeneity in the cognitive profile of bipolar disorder (BD) due to the presence of three underlying cognitive subgroups characterized as: Globally impaired, selectively impaired, or cognitively intact. In an effort to determine whether these subgroups are differentially related to genetic risk for the illness, we investigated whether cognitive deficits were more pronounced in unaffected siblings (UAS) of BD probands within identified clusters. Methods Cluster analysis was used to identify cognitive clusters in BD (N = 60). UAS (N = 49) were classified into groups according to their proband sibling's cluster assignment; comparisons were ma..
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Awarded by National Institute of Mental Health
Funding Acknowledgements
The authors gratefully acknowledge patients and their relatives who took part in the research. This work was supported by grants from the National Institute of Mental Health (grant numbers: R03MH079995; K23MH077807; R01MH100125 to KEB) and the Veterans Health Administration (grant number: I01CX000995-03 to KEB).