Journal article
Muscle sympathetic nerve activity is associated with elements of the plasma lipidomic profile in young asian adults
N Eikelis, EA Lambert, S Phillips, CI Sari, PA Mundra, JM Weir, K Huynh, MT Grima, NE Straznicky, JB Dixon, MP Schlaich, PJ Meikle, GW Lambert
Journal of Clinical Endocrinology and Metabolism | ENDOCRINE SOC | Published : 2017
DOI: 10.1210/jc.2016-3738
Abstract
Background: Asian subjects are at increased cardio-metabolic risk at comparatively lower body mass index (BMI) compared with white subjects. Sympathetic nervous system activation and dyslipidemia, both characteristics of increased adiposity, appear to be related. We therefore analyzed the association of muscle sympathetic nerve activity (MSNA) with the plasma lipidomic profile in young adult Asian and white subjects. Methods: Blood samples were collected from 101 participants of either Asian or white background (age, 18 to 30 years; BMI, 28.1 6 5.9 kg/m2). Lipids were extracted from plasma and analyzed using electrospray ionization-tandem mass spectrometry. MSNA was quantified using microneu..
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Funding Acknowledgements
G.W.L. and M.P.S. are supported by career fellowships from the National Health and Medical Research Council. G.W.L. and M.P.S. are investigators in studies sponsored by Medtronic. The laboratories of G.W.L. and M.P.S. currently receive research funding from Medtronic. G.W.L. has acted as a consultant for Medtronic and has received honoraria or travel support for presentations from Pfizer, Wyeth Pharmaceuticals, Servier, and Medtronic. M.P.S. serves on scientific advisory boards for Abbott (formerly Solvay) Pharmaceuticals, BI, Novartis Pharmaceuticals, and Medtronic and has received honoraria and travel support from Abbott, BI, Servier, Novartis, and Medtronic. The remaining authors have nothing to disclose.