Immunogenicity and immunologic memory of meningococcal C conjugate vaccine in premature infants.
Clare L Collins, Jens U Ruggeberg, Gail Balfour, Helen Tighe, Marion Archer, Jane Bowen-Morris, Linda Diggle, Ray Borrow, Paul Balmer, Jim P Buttery, E Richard Moxon, Andrew J Pollard, Paul T Heath
Pediatr Infect Dis J | Published : 2005
BACKGROUND: Protein-polysaccharide conjugate vaccines against Neisseria meningitidis serogroup C were introduced into the U.K. routine immunization schedule in 1999. This study is the first to describe both persistence of antibody and evidence for induction of immune memory using meningococcal C conjugate (MCC) vaccine in preterm infants. METHODS: Immunogenicity and induction of immunologic memory by as MCC vaccine was assessed in premature infants; 62 preterm and 60 term controls received MCC at the accelerated schedule (2, 3 and 4 months of age). A meningococcal C polysaccharide challenge was administered at 12 months of age. RESULTS: Both groups achieved similar protective titers after pr..View full abstract