Intraoperative dexamethasone does not increase the risk of postoperative wound infection: A propensity score-matched post hoc analysis of the ENIGMA-II trial (EnDEX)

T Corcoran; J Kasza; TG Short; E O'Loughlin; MTV Chan; K Leslie; A Forbes; M Paech; P Myles; S Wallace; W Galagher; C Farrington; A Ditoro; P Peyton; S Baulch; S Sidiropoulos; R Bulach; D Bryant; V Mitteregger; S Bolsin; C Osborne; R McRae; M Backstrom; R Cotter; S March; B Silbert; S Said; R Halliwell; J Cope; D Fahlbusch; D Crump; G Thompson; A Jefferies; T McCulloch; M Reeves; N Buckley; T Tidyl; T Schricker; R Lattermann; D Iannuzzi; S Beattie; J Carroll; M Jacka; C Bryden; N Badner; M Tsang; B Cheng; A Fong; L Chu; E Koo; N Mohd; LE Ming; C Yin Wang; D Campbell; D McAllister; S Walker; S Olliff; R Kennedy; A Eldawlatly; T Alzahrani; N Chua; G Haller; I Pichon; R Sneyd; H McMillan; I Parkinson; G Rousseau; A Brennan; P Balaji; J Cupitt; J Nightingale; G Kunst; M Dickinson; T Saran; B Subramaniam; V Banner-Godspeed; D Sessler; J Liu; A Kurz; B Hesler; A Fu; C Egan; A Fiffick; M Hutcherson; A Turan; A Naylor; D Obal; E Cooke

Journal article

Intraoperative dexamethasone does not increase the risk of postoperative wound infection: A propensity score-matched post hoc analysis of the ENIGMA-II trial (EnDEX)

T Corcoran, J Kasza, TG Short, E O'Loughlin, MTV Chan, K Leslie, A Forbes, M Paech, P Myles, S Wallace, W Galagher, C Farrington, A Ditoro, P Peyton, S Baulch, S Sidiropoulos, R Bulach, D Bryant, V Mitteregger, S Bolsin Show all

British Journal of Anaesthesia | ELSEVIER SCI LTD | Published : 2017

DOI: 10.1093/bja/aew446

Abstract

Background. In a post hoc analysis of the ENIGMA-II trial, we sought to determine whether intraoperative dexamethasone was associated with adverse safety outcomes. Methods. Inverse probability weighting with estimated propensity scores was used to determine the association of dexamethasone administration with postoperative infection, quality of recovery, and adverse safety outcomes for 5499 of the 7112 non-cardiac surgery subjects enrolled in ENIGMA-II. Results. Dexamethasone was administered to 2178 (40%) of the 5499 subjects included in this analysis and was not associated with wound infection [189 (8.7%) vs 275 (8.3%); propensity score-adjusted relative risk (RR) 1.10; 95% confidence inte..

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University of Melbourne Researchers

Kate Leslie Author

Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

Australian National Health and Medical Research Council (NHMRC, ID 436677); Australian and New Zealand College of Anaesthetists; Heart and Stroke Foundation of Quebec; Heart and Stroke Foundation of Ontario, Canada; General Research Fund of the Research Grant Council, Hong Kong Special Administrative Region, China; Australian NHMRC Practitioner's Fellowship (to P.M.).