Deterioration of visuospatial associative memory following a first psychotic episode: a long-term follow-up study

CMJ Wannan; CF Bartholomeusz; VL Cropley; TE Van Rheenen; A Panayiotou; WJ Brewer; TM Proffitt; L Henry; MG Harris; D Velakoulis; P McGorry; C Pantelis; SJ Wood

Journal article

Deterioration of visuospatial associative memory following a first psychotic episode: a long-term follow-up study

CMJ Wannan, CF Bartholomeusz, VL Cropley, TE Van Rheenen, A Panayiotou, WJ Brewer, TM Proffitt, L Henry, MG Harris, D Velakoulis, P McGorry, C Pantelis, SJ Wood

PSYCHOLOGICAL MEDICINE | CAMBRIDGE UNIV PRESS | Published : 2018

DOI: 10.1017/S003329171700157X

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Abstract

BACKGROUND: Cognitive deficits are a core feature of schizophrenia, and impairments in most domains are thought to be stable over the course of the illness. However, cross-sectional evidence indicates that some areas of cognition, such as visuospatial associative memory, may be preserved in the early stages of psychosis, but become impaired in later established illness stages. This longitudinal study investigated change in visuospatial and verbal associative memory following psychosis onset. METHODS: In total 95 first-episode psychosis (FEP) patients and 63 healthy controls (HC) were assessed on neuropsychological tests at baseline, with 38 FEP and 22 HCs returning for follow-up assessment a..

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University of Melbourne Researchers

Tamsyn van Rheenen Author Psychiatry

Cassandra Wannan Author Psychiatry

Christos Pantelis Author Psychiatry

Anita Panayiotou Author Psychiatry

Stephen Wood Author Centre for Youth Mental Health

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Grants

Awarded by NHMRC

Awarded by Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award (US)

Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

The study was supported by NHMRC Project Grants (IDs: 970598, 981112, 145627) and NHMRC Program Grants (ID: 350241, 566529). Prof C. Pantelis was supported by a NHMRC Senior Principal Research Fellowship (628386 & 1105825), and a Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award (US; Grant ID: 18722). Prof Patrick McGorry was supported by a NHMRC senior principal research fellowship. Dr Van Rheenen was supported by a National Health and Medical Research Council (NHMRC) Early Career Fellowship (APP1088785).