A classification algorithm for predicting progression from normal cognition to mild cognitive impairment across five cohorts: The preclinical AD consortium.
Alden L Gross, Jason J Hassenstab, Sterling C Johnson, Lindsay R Clark, Susan M Resnick, Melissa Kitner-Triolo, Colin L Masters, Paul Maruff, John C Morris, Anja Soldan, Corinne Pettigrew, Marilyn S Albert
Alzheimer's & dementia (Amsterdam, Netherlands) | Published : 2017
INTRODUCTION: We established a method for diagnostic harmonization across multiple studies of preclinical Alzheimer's disease and validated the method by examining its relationship with clinical status and cognition. METHODS: Cognitive and clinical data were used from five studies (N = 1746). Consensus diagnoses established in each study used criteria to identify progressors from normal cognition to mild cognitive impairment. Correspondence was evaluated between these consensus diagnoses and three algorithmic classifications based on (1) objective cognitive impairment in 2+ tests only; (2) a Clinical Dementia Rating (CDR) of ≥0.5 only; and (3) both. Associations between baseline cognitive pe..View full abstract