In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism

Roberto Salvatori; Serban Radian; Yoan Diekmann; Donato Iacovazzo; Alessia David; Plamena Gabrovska; Giorgia Grassi; Anna-Marie Bussell; Karen Stals; Astrid Weber; Richard Quinton; Elizabeth C Crowne; Valentina Corazzini; Lou Metherell; Tara Kearney; Daniel Du Plessis; Ajay Kumar Sinha; Atik Baborie; Anne-Lise Lecoq; Philippe Chanson; Olaf Ansorge; Sian Ellard; Peter J Trainer; David Balding; Mark G Thomas; Marta Korbonits

Journal article

In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism

Roberto Salvatori, Serban Radian, Yoan Diekmann, Donato Iacovazzo, Alessia David, Plamena Gabrovska, Giorgia Grassi, Anna-Marie Bussell, Karen Stals, Astrid Weber, Richard Quinton, Elizabeth C Crowne, Valentina Corazzini, Lou Metherell, Tara Kearney, Daniel Du Plessis, Ajay Kumar Sinha, Atik Baborie, Anne-Lise Lecoq, Philippe Chanson Show all

European Journal of Endocrinology | BIOSCIENTIFICA LTD | Published : 2017

DOI: 10.1530/EJE-17-0293

University of Melbourne Researchers

David Balding Author Mathematics and Statistics

Grants

Awarded by EC-REA Marie Sklodowska-Curie IEF

Awarded by MRC

Funding Acknowledgements

S R was supported by the EC-REA Marie Sklodowska-Curie IEF postdoctoral fellowship (grant 303006/2011). A D was supported by an MRC postdoctoral fellowship (grant MR/K021613/1). D I is supported by a Diabetes UK George Alberti Clinical Research Training Fellowship. M K's work on familial pituitary adenomas is supported by the Medical Research Council, Barts and the London Charity and Pfizer Ltd.