Journal article

Long-Lived Epidermal Cancer-Initiating Cells

Marina Youssef, Andrew Cuddihy, Charbel Darido

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | MDPI | Published : 2017

Abstract

Non-melanomatous skin cancers (NMSCs), which include basal and squamous cell carcinoma (BCC and SCC respectively), represent a significant burden on the population, as well as an economic load to the health care system; yet treatments of these preventable cancers remain ineffective. Studies estimate that there has been a 2-fold increase in the incidence of NMSCs between the 1960s and 1980s. The increase in cases of NMSCs, as well as the lack of effective treatments, makes the need for novel therapeutic approaches all the more necessary. To rationally develop more targeted treatments for NMSCs, a better understanding of the cell of origin, in addition to the underlying pathophysiological mech..

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Grants

Awarded by VCA Clare Oliver Memorial Fellowship


Awarded by Australian National Health and Medical Research (NHMRC)


Awarded by Association for International Cancer Research (AICR)


Funding Acknowledgements

Andrew Cuddihy is supported by a grant from the Peter Mac Foundation. Charbel Darido is a Victorian Cancer Agency (VCA) Mid-Career Research Fellow (CR_16/5985) and a previous Fellow of the VCA Clare Oliver Memorial Fellowship (COF11_04). Projects associated with this Review were supported by grants from the Australian National Health and Medical Research (NHMRC, APP1049870, APP1106697) and by a grant from The Association for International Cancer Research (AICR, 11-0060).