Journal article

Alternative splicing and start sites: Lessons from the Grainyhead-like family

Lee B Miles, Sebastian Dworkin, Charbel Darido

DEVELOPMENTAL BIOLOGY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2017

Abstract

The two main mechanisms that expand the proteomic output of eukaryotic genes are alternative splicing and alternative translation initiation signals. Despite being essential to generate isoforms of gene products that create functional diversity during development, the impact of these mechanisms on fine-tuning regulatory gene networks is still underappreciated. In this review, we use the Grainyhead-like (Grhl) family as a case study to illustrate the importance of isoforms when investigating transcription factor family function during development and disease, and highlight the potential for differential modulation of downstream target genes. We provide insights into the importance of consider..

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Grants

Awarded by Australian National Health and Medical Research (NHMRC)


Awarded by Australian Research Council (ARC) Discovery Early Career Researcher Awards (DECRA)


Awarded by VCA Clare Oliver Memorial


Awarded by Association for International Cancer Research (AICR)


Funding Acknowledgements

The authors were supported by grants from the Australian National Health and Medical Research (NHMRC, APP1063837 and APP1106697) and from the Australian Research Council (ARC) Discovery Early Career Researcher Awards (DECRA, DE140100500). CD is a Victorian Cancer Agency (VCA) Mid-Career Fellow (CR_16/5985) and was supported by a fellowship from the VCA Clare Oliver Memorial (COF11_04) and by a Grant (11-0060) from The Association for International Cancer Research (AICR).