MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression
Christopher R Shaler, Joshua Choi, Patrick T Rudak, Arash Memarnejadian, Peter A Szabo, Mauro E Tun-Abraham, Jamie Rossjohn, Alexandra J Corbett, James McCluskey, John K McCormick, Olivier Lantz, Roberto Hernandez-Alejandro, SM Mansour Haeryfar
PLOS BIOLOGY | PUBLIC LIBRARY SCIENCE | Published : 2017
Superantigens (SAgs) are potent exotoxins secreted by Staphylococcus aureus and Streptococcus pyogenes. They target a large fraction of T cell pools to set in motion a "cytokine storm" with severe and sometimes life-threatening consequences typically encountered in toxic shock syndrome (TSS). Given the rapidity with which TSS develops, designing timely and truly targeted therapies for this syndrome requires identification of key mediators of the cytokine storm's initial wave. Equally important, early host responses to SAgs can be accompanied or followed by a state of immunosuppression, which in turn jeopardizes the host's ability to combat and clear infections. Unlike in mouse models, the me..View full abstract
Awarded by Canadian Institutes of Health Research (CIHR)
Canadian Institutes of Health Research (CIHR) http://www.cihr-irsc.gc.ca/e/193.html (grant number MOP-130465). This work was supported by an operating grant to S.M. Mansour Haeryfar. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.