Journal article

Genetic diversity in the C-terminus of merozoite surface protein 1 among Plasmodium knowlesi isolates from Selangor and Sabah Borneo, Malaysia

Nan Jiun Yap, Xiang Ting Goh, Anson V Koehler, Timothy William, Tsin Wen Yeo, Indra Vythilingam, Robin B Gasser, Yvonne AL Lim



Plasmodium knowlesi, a malaria parasite of macaques, has emerged as an important parasite of humans. Despite the significance of P. knowlesi malaria in parts of Southeast Asia, very little is known about the genetic variation in this parasite. Our aim here was to explore sequence variation in a molecule called the 42kDa merozoite surface protein-1 (MSP-1), which is found on the surface of blood stages of Plasmodium spp. and plays a key role in erythrocyte invasion. Several studies of P. falciparum have reported that the C-terminus (a 42kDa fragment) of merozoite surface protein-1 (MSP-142; consisting of MSP-119 and MSP-133) is a potential candidate for a malaria vaccine. However, to date, no..

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Awarded by University of Malaya/Ministry of Higher Education High Impact Research

Awarded by University of Malaya

Awarded by Endeavour program

Funding Acknowledgements

Funding from the Australian Research Council (ARC), the National Health and Medical Research Council (NHMRC) of Australia, Melbourne Water Corporation (R.B.G. et al.) and University of Malaya/Ministry of Higher Education High Impact Research (UM.C/625/1/HIR/MOHE/MED/23), University of Malaya (PG056-2013A) (Y.A.L.L. et al.) are gratefully acknowledged. Support from the Endeavour program (ID 4731-2015) is also gratefully acknowledged (NJY).