Journal article

Short-term poor glycemic control and retinal microvascular changes in pediatric Type 1 Diabetes patients in Singapore: a pilot study

Ling-Jun Li, Ecosse Lamoureux, Tien Yin Wong, Ngee Lek

BMC OPHTHALMOLOGY | BMC | Published : 2017

Abstract

BACKGROUND: Poor glycemic control in Type 1 Diabetes (T1D) patients is strongly associated with an increased risk of diabetes-related microvascular complications later in life, but it is unclear whether short period of poor glycemic control in children with T1D can cause evident microvascular morphological changes long before any pathological manifestation. Our study aimed to investigate the longitudinal association between poor glycemic control and subsequent changes in retinal microvasculature, in a pilot study of 55 pediatric T1D patients from Singapore after a one-year follow-up. METHODS: This is a hospital-based, exposure-matched and retrospective longitudinal study. A total of 55 T1D p..

View full abstract

Grants

Awarded by Singapore National Medical Research Council Transition Award (NMRC)


Awarded by Singapore National Medical Research Council Research Training Fellowship


Funding Acknowledgements

Dr. Ling-Jun Li is funded by Singapore National Medical Research Council Transition Award (NMRC TA/0027/2014) and Singapore National Medical Research Council Research Training Fellowship (NMRC/Fellowship/0029/2014). Dr. Ngee Lek is funded by Singapore National Medical Research Council Transition Award (NMRC TA/0037/2015) and Clinician Scientist/Clinician Investigator Salary Support Programme (CS/CISSP).