Journal article

Association between switching antiepileptic drug products and healthcare utilization: A systematic review

Patrick Kwan, Andre Palmini



AIMS: There is ongoing concern whether switching between different antiepileptic drug (AED) products may compromise patient care. We systematically reviewed changes in healthcare utilization following AED switch. METHODS: We searched MEDLINE and EMBASE databases (1980-October 2016) for studies that assessed the effect of AED switching in patients with epilepsy on outpatient visits, emergency room visits, hospitalization and hospital stay duration. RESULTS: A total of 14 articles met the inclusion criteria. All were retrospective studies. Four provided findings for specific AEDs only (lamotrigine, topiramate, phenytoin and divalproex), 9 presented pooled findings from multiple AEDs, and 1 stu..

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Funding Acknowledgements

Patrick Kwan has received research grants from the National Health and Medical Research Council of Australia, the Australian Research Council, the US NIH, Hong Kong Research Grants Council, Innovation and Technology Fund, Health and Health Services Research Fund, and Health and Medical Research Fund. His institution also received speaker or consultancy fees and/or research grants from Eisai, GlaxoSmithKline, Johnson & Johnson, Pfizer, and UCB Pharma. Andre Palmini holds a grant from CNPq Brazilian Research Agency and has received funds from Novartis, Abbott, UCB, Janssen-Cilag and Eli-Lilly as board member, invited speaker, for development of educational material and to cover meeting/travel expenses unrelated to the present study.