Journal article

Mammographic density and ageing: A collaborative pooled analysis of cross-sectional data from 22 countries worldwide

Anya Burton, Gertraud Maskarinec, Beatriz Perez-Gomez, Celine Vachon, Hui Miao, Martin Lajous, Ruy Lopez-Ridaura, Megan Rice, Ana Pereira, Maria Luisa Garmendia, Rulla M Tamimi, Kimberly Bertrand, Ava Kwong, Giske Ursin, Eunjung Lee, Samera A Qureshi, Huiyan Ma, Sarah Vinnicombe, Sue Moss, Steve Allen Show all



BACKGROUND: Mammographic density (MD) is one of the strongest breast cancer risk factors. Its age-related characteristics have been studied in women in western countries, but whether these associations apply to women worldwide is not known. METHODS AND FINDINGS: We examined cross-sectional differences in MD by age and menopausal status in over 11,000 breast-cancer-free women aged 35-85 years, from 40 ethnicity- and location-specific population groups across 22 countries in the International Consortium on Mammographic Density (ICMD). MD was read centrally using a quantitative method (Cumulus) and its square-root metrics were analysed using meta-analysis of group-level estimates and linear reg..

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Awarded by US National Cancer Institute of the National Institutes of Health

Awarded by Australia-Australian NHMRC

Awarded by Chile-Fondecyt

Awarded by Chile-World Cancer Research Fund

Awarded by Rep. of Korea: Asan Medical Center, Seoul, Republic of Korea

Awarded by Malaysia-Ministry of Education University

Awarded by Malaysia-University Malaya

Awarded by Mexico-American Institute for Cancer Research

Awarded by Poland-Polish-Norwegian Research Programme

Awarded by Spain-Spain's Health Research Fund (Fondo de Investigacion Santiaria)

Awarded by Spain-Spanish Federation of Breast Cancer Patients (FECMA)

Awarded by UK-EPSRC

Awarded by UK-Breast Cancer Campaign

Awarded by UK-Cancer Research UK

Awarded by US-National Cancer Institute

Awarded by US-Cancer Center Support Grant

Awarded by Cancer Research UK

Awarded by National Institute for Health Research

Awarded by National Breast Cancer Foundation


Funding Acknowledgements

This work was supported by grant R03CA167771 from the US National Cancer Institute of the National Institutes of Health, and by the International Agency for Research on Cancer. Original studies were supported, according to country, by: Australia-Australian National Breast Cancer Foundation (to JSt), MCCS by VicHealth, Cancer Council Victoria and Australian NHMRC grants 209057, 251553 and 504711, cases and their vital status were ascertained through the Victorian Cancer Registry and the Australian Institute of Health and Welfare, including the National Death Index and the Australian Cancer Database; Canada-the National Cancer Institute of Canada (to NB); Chile-Fondecyt 11100238 (to MLG), 1120326, 1130277, 3130532, World Cancer Research Fund 2010/245, Ellison Medical Foundation Grant (to AP); Iran-Isfahan University of Medical Sciences; Israel-The Israel Cancer Association; Rep. of Korea: Asan Medical Center, Seoul, Republic of Korea, Grant No. 2010-0811; Malaysia-Sime Darby LPGA Tournament, the Ministry of Education University Malaya High Impact Research Grant UM.C/HIR/MOHE/06 and University Malaya Research Grant No RP046B-15HTM; Mexico-Ministry of Education of Mexico and ISSSTEs Medical Directorate staff and regional office in Jalisco for technical and administrative support, National Council of Science and Technology (Mexico) and the American Institute for Cancer Research (10A035); Netherlands EPIC-NL-Europe against Cancer Programme of the European Commission (SANCO), Dutch Ministry of Health, Dutch Cancer Society, ZonMW the Netherlands Organisation for Health Research and Development, and the World Cancer Research Fund; Poland-Polish-Norwegian Research Programme (PNRF-243-AI-1/07); Singapore-Clinician Scientist Award from National Medical Research Council and National University Cancer Institute Singapore (NCIS) Centre grant programme from National Medical Research Council; South Africa-Pink Drive; Spain-Spains Health Research Fund (Fondo de Investigacion Santiaria) PI060386 and PS09/0790, and Spanish Federation of Breast Cancer Patients (FECMA) EPY1169-10; Turkey-Roche Mustahzarlari San. A.S., Istanbul, Turkey; UK-EPSRC and EP/K020439/1 (JHi), Breast Cancer Campaign (2007MayPR23), Cancer Research UK (G186/11; C405/A14565), Da Costa Foundation; US-National Cancer Institute R01CA85265, R37 CA54281, R01 CA97396, P50 CA116201, R01 CA177150, R01 CA140286, Cancer Center Support Grant CA15083; CA131332, CA124865, UM1 CA186107, UM1 CA176726 and the Susan G. Komen Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.