Journal article

Natural immune response to Plasmodium vivax alpha-helical coiled coil protein motifs and its association with the risk of P. vivax malaria

Nora Cespedes, Connie SN Li Wai Suen, Cristian Koepfli, Camila T Franca, Ingrid Felger, Issa Nebie, Myriam Arevalo-Herrera, Ivo Mueller, Giampietro Corradin, Socrates Herrera

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2017

Abstract

Protein α-helical coiled coil structures are known to induce antibodies able to block critical functions in different pathogens. In a previous study, a total of 50 proteins of Plasmodium vivax erythrocytic asexual stages containing α-helical coiled coil structural motifs were identified in silico, and the corresponding peptides were chemically synthesized. A total of 43 peptides were recognized by naturally acquired antibodies in plasma samples from both Papua New Guinea (PNG) and Colombian adult donors. In this study, the association between IgG antibodies to these peptides and clinical immunity was further explored by measuring total IgG antibody levels to 24 peptides in baseline samples f..

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Grants

Awarded by Colciencias


Awarded by NIAID (ICEMR)


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

This work was supported by Colciencias (Contract 278-2008, Contract 360-2011 and Contract 719-2013) and a grant from NIAID (ICEMR grant U19A1089702). Also, this work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.