Journal article

White matter microstructure in boys with persistent depressive disorder

Veronika Vilgis, Alasdair Vance, Ross Cunnington, Timothy J Silk

JOURNAL OF AFFECTIVE DISORDERS | ELSEVIER SCIENCE BV | Published : 2017

Abstract

BACKGROUND: Persistent depressive symptoms in children and adolescents are considered a risk factor for the development of major depressive disorder (MDD) later in life. Previous research has shown alterations in white matter microstructure in pediatric MDD but discrepancies exist as to the specific tracts affected. The current study aimed to improve upon previous methodology and address the question whether previous findings of lower fractional anisotropy (FA) replicate in a sample of children with persistent depressive disorder characterized by mild but more chronic symptoms of depression. METHODS: White matter microstructure was examined in 25 boys with persistent depressive disorder and ..

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Grants

Awarded by NHMRC


Funding Acknowledgements

NHMRC project grants 384419 and 569533 provided funds for the data collection. The study was also supported by the Murdoch Childrens Research Institute, the Royal Children's Hospital, The Royal Children's Hospital Foundation, Department of Paediatrics The University of Melbourne and the Victorian Government's Operational Infrastructure Support Program. TS was supported by a NHMRC Career Development Award.