Journal article

Tuberculosis: An Infection-Initiated Autoimmune Disease?

Paul Elkington, Marc Tebruegge, Salah Mansour

Trends in Immunology | ELSEVIER SCI LTD | Published : 2016

Abstract

Tuberculosis (TB) is caused by Mycobacterium tuberculosis (Mtb) and provided original proof that an infectious agent can cause human disease. However, key steps in TB pathogenesis remain poorly understood. We propose that autoimmunity is a critical and overlooked process driving pathology in TB, and present clinical and experimental observations supporting this hypothesis.