Tuberculosis: An Infection-Initiated Autoimmune Disease?
Paul Elkington, Marc Tebruegge, Salah Mansour
Trends in Immunology | ELSEVIER SCI LTD | Published : 2016
Tuberculosis (TB) is caused by Mycobacterium tuberculosis (Mtb) and provided original proof that an infectious agent can cause human disease. However, key steps in TB pathogenesis remain poorly understood. We propose that autoimmunity is a critical and overlooked process driving pathology in TB, and present clinical and experimental observations supporting this hypothesis.
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Awarded by National Institute for Health Research
Awarded by Medical Research Council
Awarded by NIAID NIH HHS