Journal article

Evidence-based approach to harmonised reference intervals

Gus Koerbin, Ken Andrew Sikaris, Graham Ross Dallas Jones, Julie Ryan, Maxine Reed, Jill Tate

Clinica Chimica Acta | ELSEVIER SCIENCE BV | Published : 2014

Abstract

Although we are in the era of evidence-based medicine, there is still a substantial gap between theory and current practice with the application of reference intervals as decision making tools. Different laboratories may have different reference intervals for the same tests using the same analytical methods and platforms. These differences have the potential to confuse physicians making the assessment and monitoring of patients more difficult by providing discordant information. This paper attempts to demonstrate how to use evidence-based approach for harmonising reference intervals. In order to consider harmonisation we must first have an appreciation of the various factors that influence t..

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University of Melbourne Researchers