Journal article
Neurological heterotopic ossification following spinal cord injury is triggered by macrophage-mediated inflammation in muscle
F Genêt, I Kulina, C Vaquette, F Torossian, S Millard, AR Pettit, NA Sims, A Anginot, B Guerton, IG Winkler, V Barbier, JJ Lataillade, MC Le Bousse-Kerdilès, DW Hutmacher, JP Levesque
Journal of Pathology | WILEY | Published : 2015
DOI: 10.1002/path.4519
Abstract
Neurological heterotopic ossification (NHO) is the abnormal formation of bone in soft tissues as a consequence of spinal cord or traumatic brain injury. NHO causes pain, ankyloses, vascular and nerve compression and delays rehabilitation in this high-morbidity patient group. The pathological mechanisms leading to NHO remain unknown and consequently there are no therapeutic options to prevent or reduce NHO. Genetically modified mouse models of rare genetic forms of heterotopic ossification (HO) exist, but their relevance to NHO is questionable. Consequently, we developed the first model of spinal cord injury (SCI)-induced NHO in genetically unmodified mice. Formation of NHO, measured by micro..
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
Funding Acknowledgements
IGW and JPL are supported by a Career Development Fellowship (No. 1033736) and a Research Fellowship (No. 1044091), respectively, from the National Health and Medical Research Council (NHMRC) of Australia. This study was supported in part by the Mater Foundation (to JPL), a NHMRC Project Grant (to NAS), Fondation BNP-Paribas (to FG), Assistance Publique - Hopitaux de Paris (to FG), Universite de Versailles Saint Quentin (to FG), Institut National de la Sante et de la Recherche Medicale (to MCLBK), Service de Sante des Armees (to JJL) and travel fellowships from the Forum for European-Australian Science and Technology Cooperation, IPSEN, MERZ and ALLERGAN (to FG).