Journal article

Regulating Delta FosB expression in adult tet-off-Delta Fos beta transgenic mice alters bone formation and bone mass

NA Sims, G Sabatakos, JS Chen, MB Kelz, EJ Nestler, R Baron

BONE | ELSEVIER SCIENCE INC | Published : 2002

Abstract

The DeltaFosB isoforms are naturally occurring AP-1 family members that increase bone volume via a cell-autonomous effect on osteoblastic bone formation. Mice overexpressing DeltaFosB demonstrate a very high level of bone formation, resulting in a progressive osteosclerosis. Despite the linkage of bone formation and resorption in physiological systems, no alteration in bone resorption was detected in mice overexpressing DeltaFosB. To determine whether altering DeltaFosB expression can regulate bone formation independently of bone resorption in adult mice, we used the Tet-Off-inducible transgene system to induce or block transgenic DeltaFosB overexpression and thereby regulate bone formation ..

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