Journal article

AN EXERCISE CHALLENGE PROTOCOL FOR EPIDEMIOLOGIC STUDIES OF ASTHMA IN CHILDREN - COMPARISON WITH HISTAMINE CHALLENGE

MM HABY, SD ANDERSON, JK PEAT, CM MELLIS, BG TOELLE, AJ WOOLCOCK

EUROPEAN RESPIRATORY JOURNAL | MUNKSGAARD INT PUBL LTD | Published : 1994

Abstract

We investigated whether an exercise challenge protocol is suitable for measuring bronchial responsiveness in epidemiological studies of asthma in children, and determined its comparability with histamine challenge. The exercise challenge was 6 minutes of outdoor, free-range running at 85-90% of maximum heart rate, measured by heart rate monitor. Nose clips were worn. Distance run was measured to estimate oxygen consumption. Water content of the inspired air was < 10 mg H2O.l-1. Histamine challenge was by the rapid method. We used questionnaires to measure respiratory symptoms and skin prick tests to measure atopy. A total of 96 children aged 8-11 years were studied. Bronchial hyperresponsive..

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