Journal article
Risk factors for pandemic (H1N1) 2009 virus seroconversion among hospital staff, Singapore
MIC Chen, VJM Lee, I Barr, C Lin, R Goh, C Lee, B Singh, J Tan, WY Lim, AR Cook, B Ang, A Chow, BH Tan, J Loh, R Shaw, KS Chia, RTP Lin, YS Leo
Emerging Infectious Diseases | CENTERS DISEASE CONTROL | Published : 2010
Abstract
We describe incidence and risk factors for pandemic (H1N1) 2009 virus infection in healthcare personnel during the June-September 2009 epidemic in Singapore. Personnel contributed 3 serologic samples during June-October2009, with seroconversion defined as a ≥4-fold increase in hemagglutination inhibition titers to pandemic (H1N1) 2009.Of 531 participants, 35 showed evidence of seroconversion. Seroconversion rates were highest in nurses (28/290) and lowest in allied health staff (2/116). Significant risk factor son multivariate analysis were being a nurse (adjusted odd sratio [a OR] 4.5, 95% confidence interval [CI] 1.0-19.6) and working in pandemic (H1N1) 2009 isolation wards (aOR4.5, 95% CI..
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Awarded by National Medical Research Council of Singapore
Funding Acknowledgements
This project was funded by the National Medical Research Council of Singapore (NMRC/H1N1O/002/2009). The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Ageing.