Journal article
Serological response in RT-PCR confirmed h1n1-2009 influenza a by hemagglutination inhibition and virus neutralization assays: An observational study
MI Chen, IG Barr, GCH Koh, VJ Lee, CPS Lee, R Shaw, C Lin, J Yap, AR Cook, BH Tan, JP Loh, T Barkham, VTK Chow, RTP Lin, YS Leo
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2010
Abstract
Background: We describe the serological response following H1N1-2009 influenza A infections confirmed by reversetranscriptase polymerase chain reaction (RT-PCR). Methodology and Principal Findings: The study included patients admitted to hospital, subjects of a seroepidemiologic cohort study, and participants identified from outbreak studies in Singapore. Baseline (first available blood sample) and follow-up blood samples were analyzed for antibody titers to H1N1-2009 and recently circulating seasonal influenza A virus strains by hemagglutination inhibition (HI) and virus micro-neutralization (VM) assays. 267 samples from 118 cases of H1N1- 2009 were analyzed. Geometric mean titers by HI pea..
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Awarded by National Medical Research Council of Singapore
Funding Acknowledgements
The project was funded as part of the grant NMRC/H1N1O/002/2009 awarded by the National Medical Research Council of Singapore (www.nmrc.gov.sg/corp/index.aspx). The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Ageing. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.