Journal article

The emerging threat of multidrug-resistant Gram-negative bacteria in urology

Hosam M Zowawi, Patrick NA Harris, Matthew J Roberts, Paul A Tambyah, Mark A Schembri, M Diletta Pezzani, Deborah A Williamson, David L Paterson

NATURE REVIEWS UROLOGY | NATURE PORTFOLIO | Published : 2015

Abstract

Antibiotic resistance in Gram-negative uropathogens is a major global concern. Worldwide, the prevalence of Enterobacteriaceae that produce extended-spectrum β-lactamase or carbapenemase enzymes continues to increase at alarming rates. Likewise, resistance to other antimicrobial agents including aminoglycosides, sulphonamides and fluoroquinolones is also escalating rapidly. Bacterial resistance has major implications for urological practice, particularly in relation to catheter-associated urinary tract infections (UTIs) and infectious complications following transrectal-ultrasonography-guided biopsy of the prostate or urological surgery. Although some new drugs with activity against Gram-neg..

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Grants

Awarded by Ministry of National Guard, Health Affairs, King Abdullah International Medical Research Centre, Saudi Arabia


Funding Acknowledgements

H.M.Z. acknowledges an academic scholarship from the government of Saudi Arabia to pursue postgraduate studies in the field of clinical microbiology and infectious diseases, and research support from the Ministry of National Guard, Health Affairs, King Abdullah International Medical Research Centre, Saudi Arabia (project no. IRBC/193/12). P.N.A.H. is supported by an Australian Postgraduate Award from the University of Queensland, Australia. M.J.R. is supported by a Doctor in Training Research Scholarship from Avant Mutual Group Ltd., a Cancer Council Queensland PhD Scholarship and Professor William Burnett Research Fellowship from the Discipline of Surgery, School of Medicine, The University of Queensland, Australia.