Survey of the bp/tee genes from clinical group A streptococcus isolates in New Zealand - implications for vaccine development
John D Steemson, Nicole J Moreland, Deborah Williamson, Julie Morgan, Philip E Carter, Thomas Proft
Journal of Medical Microbiology | SOC GENERAL MICROBIOLOGY | Published : 2014
Group A streptococcus (GAS) is responsible for a wide range of diseases ranging from superficial infections, such as pharyngitis and impetigo, to life-threatening diseases, such as toxic shock syndrome and acute rheumatic fever (ARF). GAS pili are hair-like extensions protruding from the cell surface and consist of highly immunogenic structural proteins: the backbone pilin (BP) and one or two accessory pilins (AP1 and AP2). The protease-resistant BP builds the pilus shaft and has been recognized as the T-antigen, which forms the basis of a major serological typing scheme that is often used as a supplement to M typing. A previous sequence analysis of the bp gene (tee gene) in 39 GAS isolates ..View full abstract
This work was supported by research grants from Lottery Health New Zealand and the Maurice Wilkins Centre for Biodiscovery, University of Auckland. N.M. is a New Zealand Heart Foundation Research Fellow.