Baseline prevalence of antimicrobial resistance and subsequent infection following prostate biopsy using empirical or altered prophylaxis: A bias-adjusted meta-analysis
Matthew J Roberts, Deborah A Williamson, Paul Hadway, Suhail AR Doi, Robert A Gardiner, David L Paterson
International Journal of Antimicrobial Agents | ELSEVIER | Published : 2014
Transrectal ultrasound-guided prostate biopsy (TRUSPB) is a commonly performed urological procedure. Recent studies suggest that pre-biopsy screening for fluoroquinolone-resistant (FQ-R) pathogens may be useful in reducing post-biopsy infections. We sought to determine the baseline prevalence of fluoroquinolone (FQ) resistance in rectal flora and to investigate the relationship between pre-biopsy carriage of FQ-R pathogens and the risk of post-TRUSPB infection. Electronic databases were searched for related literature. Studies were assessed for methodological quality and comparable outcomes prior to meta-analysis (using quality- and random-effects models). Nine studies, representing 2541 pat..View full abstract
Funding: MJR is supported by a Doctor in Training Research Scholarship from Avant Mutual Group Ltd., Cancer Council Queensland PhD Scholarship and Professor William Burnett Research Fellowship from the Discipline of Surgery, School of Medicine, The University of Queensland. DAW is a Clinical Research Training Fellow of the Health Research Council of New Zealand. DLP receives funding from the NHMRC Practitioner Fellowship and Queensland Health Senior Clinical Research Fellowship.