Clinical and molecular correlates of virulence in Escherichia coli causing bloodstream infection following transrectal ultrasound-guided (TRUS) prostate biopsy
Deborah A Williamson, Joshua T Freeman, Stephen Porter, Sally Roberts, Siouxsie Wiles, David L Paterson, James R Johnson
Journal of Antimicrobial Chemotherapy | OXFORD UNIV PRESS | Published : 2013
OBJECTIVES: Prevention and management of Escherichia coli bacteraemia following transrectal ultrasound-guided (TRUS) prostate biopsy has become increasingly complicated by antimicrobial resistance, particularly to fluoroquinolones. Moreover, the globally disseminated, multiresistant sequence type 131 (ST131) E. coli clonal group has recently been described as a major pathogen in the setting of post-biopsy sepsis. Accordingly, we sought to further explore the clinical and molecular epidemiology of post-TRUS biopsy E. coli bacteraemia by comparing the phylogenetic, resistance and virulence characteristics of post-TRUS biopsy E. coli bloodstream isolates with E. coli bloodstream isolates from m..View full abstract
Awarded by Veterans Affairs
This material is based upon work supported in part by the Office of Research and Development, Medical Research Service, Department of Veterans Affairs (J. R. J.). D. A. W. is supported by a Clinical Research Training Fellowship from the Health Research Council of New Zealand.