Journal article
An evaluation of the Xpert MTB/RIF assay and detection of false-positive rifampicin resistance in Mycobacterium tuberculosis
DA Williamson, I Basu, J Bower, JT Freeman, G Henderson, SA Roberts
Diagnostic Microbiology and Infectious Disease | ELSEVIER SCIENCE INC | Published : 2012
Abstract
Recent reports suggest that false-positive rifampicin resistance may be assigned by the Xpert MTB/RIF assay. We analysed 169 specimens using the MTB/RIF assay. Using culture as the gold standard, we found that the assay had 100% sensitivity and specificity for detecting M. tuberculosis. However, we found that the assay incorrectly assigned rifampicin resistance in 4/13 (31%) of cases. © 2012 Elsevier Inc.