An evaluation of the Xpert MTB/RIF assay and detection of false-positive rifampicin resistance in Mycobacterium tuberculosis
Deborah A Williamson, Indira Basu, James Bower, Joshua T Freeman, Gillian Henderson, Sally A Roberts
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | ELSEVIER SCIENCE INC | Published : 2012
Recent reports suggest that false-positive rifampicin resistance may be assigned by the Xpert MTB/RIF assay. We analysed 169 specimens using the MTB/RIF assay. Using culture as the gold standard, we found that the assay had 100% sensitivity and specificity for detecting M. tuberculosis. However, we found that the assay incorrectly assigned rifampicin resistance in 4/13 (31%) of cases.