Journal article

Systematic review of the influence of chemotherapy-associated liver injury on outcome after partial hepatectomy for colorectal liver metastases

J Zhao, KMC van Mierlo, J Gomez-Ramirez, H Kim, CHC Pilgrim, P Pessaux, SS Rensen, EP van der Stok, FG Schaap, O Soubrane, T Takamoto, L Vigano, B Winkens, CHC Dejong, SWM Olde Damink

British Journal of Surgery | WILEY | Published : 2017

Abstract

BACKGROUND: The impact of chemotherapy-associated liver injury (CALI) on postoperative outcome in patients undergoing partial hepatectomy for colorectal liver metastases (CRLM) remains controversial. The objective of this study was to clarify the effect of CALI (sinusoidal dilatation (SD), steatosis and steatohepatitis) on postoperative morbidity and mortality by investigating a large data set from multiple international centres. METHODS: PubMed and Embase were searched for studies published between 1 January 2004 and 31 December 2013 with keywords 'chemotherapy', 'liver resection', 'outcome' and 'colorectal metastases' to identify potential collaborating centres. Univariable and multivariab..

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