Systematic review of the influence of chemotherapy-associated liver injury on outcome after partial hepatectomy for colorectal liver metastases
J Zhao, KMC van Mierlo, J Gomez-Ramirez, H Kim, CHC Pilgrim, P Pessaux, SS Rensen, EP van der Stok, FG Schaap, O Soubrane, T Takamoto, L Vigano, B Winkens, CHC Dejong, SWM Olde Damink
British Journal of Surgery | WILEY | Published : 2017
BACKGROUND: The impact of chemotherapy-associated liver injury (CALI) on postoperative outcome in patients undergoing partial hepatectomy for colorectal liver metastases (CRLM) remains controversial. The objective of this study was to clarify the effect of CALI (sinusoidal dilatation (SD), steatosis and steatohepatitis) on postoperative morbidity and mortality by investigating a large data set from multiple international centres. METHODS: PubMed and Embase were searched for studies published between 1 January 2004 and 31 December 2013 with keywords 'chemotherapy', 'liver resection', 'outcome' and 'colorectal metastases' to identify potential collaborating centres. Univariable and multivariab..View full abstract
Awarded by China Scholarship Council
J.Z. and K.M.C.v.M. contributed equally to this study. The authors thank H. Nguyen for thorough reading and commenting on the manuscript. J.Z. is supported by the China Scholarship Council (201207040056).