Journal article

Cross talk between type III secretion and flagellar assembly systems in Pseudomonas aeruginosa

Chantal Soscia, Abderrahman Hachani, Alain Bernadac, Alain Filloux, Sophie Bleves

Journal of Bacteriology | AMER SOC MICROBIOLOGY | Published : 2007


Pseudomonas aeruginosa cytotoxicity is linked to a type III secretion system (T3SS) that delivers effectors into the host cell. We show here that a negative cross-control exists between T3SS and flagellar assembly. We observed that, in a strain lacking flagella, T3SS gene expression, effector secretion, and cytotoxicity were increased. Conversely, we revealed that flagellar-gene expression and motility were decreased in a strain overproducing ExsA, the T3SS master regulator. Interestingly, a nonmotile strain lacking the flagellar filament (DeltafliC) presented a hyperefficient T3SS and a nonmotile strain assembling flagella (DeltamotAB) did not. More intriguingly, a strain lacking motCD gene..

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University of Melbourne Researchers