High-level antibiotic resistance in Pseudomonas aeruginosa biofilm: the ndvB gene is involved in the production of highly glycerol-phosphorylated beta-(1 -> 3)-glucans, which bind aminoglycosides
Irina Sadovskaya, Evgeny Vinogradov, Jianjun Li, Abderrahman Hachani, Karolina Kowalska, Alain Filloux
GLYCOBIOLOGY | OXFORD UNIV PRESS INC | Published : 2010
Pseudomonas aeruginosa is an opportunistic pathogen that affects immunocompromised individuals and causes life-threatening infections in cystic fibrosis (CF) patients. Colonization of CF lung by P. aeruginosa involves a biofilm mode of growth, which is promoted by the production of exopolysaccharides. These polymers are essential components of the extracellular biofilm matrix. P. aeruginosa possesses several clusters contributing to the formation of the matrix, including the pel or psl genes. In the present study, we identified anionic cyclic glucans produced by P. aeruginosa, which are associated with the matrix of strains PAKDeltaretS and PA14. Their structure has been elucidated using che..View full abstract
Awarded by EST Marie Curie
Awarded by ERA-NET Pathogenomics grant
Alain Filloux is supported by the Royal Society, the EST Marie Curie grant number MEST-CT-2005-020278 and the ERA-NET Pathogenomics grant EPS-MATRIX.